Velma is a scientist working on a secret tech w other scientists called nanites. Their goal was to infect humans w this tech; taking over the hosts brain to make all humans peaceful, eliminating hate, violence etc.. but of course, things turn bad, it isn't what Velma though, basically the nanites are to control the population to the govt's power.
Shaggy is an expert dog trainer, he works for the same company Velma does. Although, they don't know each other. At the end of the comic they show how scooby and shaggy met in a short. He saved scooby life when other dogs were going to attack and kill him in their kennel.
Scooby is in the 'smart dog project' where they implant a chip into his brain to active his talking. He also wears hi-tech gear. But Scooby was a disappointment and failure according to the scientist. He was too simple-minded. So they went and searched for other dogs to experiment on and they were successes.
Fred and Daphnie are freelance journalists, looking to solve mysteries. Daph is the reporter and Fred is the camera man.
Velma feels bad for the nanites and wants to stop it, so she contacts mystery reporter Daph to spill the beans on her show. Scooby and Shaggy come in and meet them all because of Scoobys gear; it lets him know Velma's in trouble. Fred had accidentally hit Velma thinking she was a mole rat person.
Velma tells all of them what's going on, they go back to base and she shows them around. It ends w the nanites being prematurely activated, Velma shocked and says the world is going to end now.
It was cool. Def more serious. I'll keep picking it up until I feel it shits out. But so far, I like it.