The Scientific Advancements Thread

  • Thread starter Thread starter New Editor
  • Start date Start date
Brain pacemaker helps treat Alzheimer’s disease

By Grant Brunner

Deep brain stimulation (DBS) is the use of a pacemaker-like device implanted in the brain to treat the symptoms of diseases like Parkinson’s, or other maladies such as depression. For the first time in the US, surgeons at Johns Hopkins in Baltimore, Maryland have used this technique to attempt to slow memory loss in a patient suffering from the early stages of Alzheimer’s disease.

Back in 2010, a safety study in Canada showed that patients with this device showed increased glucose metabolism over thirteen months while untreated patients suffered decreased glucose metabolism. While this new trial only has one patient so far, the second will be receiving the implant this month. It’s not just Johns Hopkins, though. The University of Toronto, the University of Pennsylvania, the University of Florida, and Banner Health System will all be implanting these so-called pacemakers into roughly forty patients over the next year. In the news release, it is explained that after recent drug trials failed to prevent the build-up of the degenerative beta amyloid plaques, the research team has been focused on using alternative methods of slowing the progression of the disease. This study clearly has a lot riding on it.

The fornix, a vital part of the brain that brings data to the hippocampus, is being targeted with this device. Essentially, the fornix is the area of the brain that converts electrical activity into chemical activity. Holes are drilled into the skull, and wires are placed on both sides of the brain. Then, the stimulator device pumps in small and unnoticeable electrical impulses upwards of 130 times per second. Half of the patients will begin the electrical treatment two weeks post-surgery, but the other half won’t have their pacemakers turned on until a full year after the surgery to provide comparison data for the study.

While the researchers are hopeful that the deep brain stimulation will be an effective tool to treat Alzheimer’s disease directly, that isn’t the end-game. Even if these studies don’t work out as planned, it will provide better information for these researchers to develop better and less-invasive treatments going forward. It’s important to note that this is in no way meant to cure Alzheimer’s disease. However, stimulating the areas of the brain that aren’t damaged yet will hopefully drastically slow the loss of memory associated with the disease.

Millions of people suffer from this debilitating disease, and that number is expected to triple in the next few decades. This study, and studies like it, are vitally important to developing effective treatments and hopefully a cure some day. If you’re interested in participating in the study, you can volunteer directly on John Hopkins’ website.
 
^^^meh...that's not something that new really. They use electrical stimulation in severe cases of Parkinsonism and Alzheimer's by injecting electrodes into the basal ganglia of the brain to stimulate activity. It's already used in severe cases, but a pacemaker I wouldn't trust since it's an automated device. I wouldn't recommend that to my patient until it's passed the Phase 3 and Phase 4 clinical trials. Even then, i'd be skeptical to recommend it unless i've exhausted every pharmaceutical option.

Besides, this isn't even something that would work on all patients with Alzheimers or Parkinsons. Parkinsons' Disease isn't even a problem with the fornix, it's a problem with the basal ganglia.

Not that the idea isn't cool, or probably even thought of before, just that it's another symptomatic treatment of the disease. We actually have plenty of those. What we want is a curative therapy for these diseases. And so far, none exists.

Again, not that a pacemaker in the fornix isn't a cool idea. Just that it's not even relevant for many cases of Alzheimer's and Parkinson's, it isn't curative, and electrical stimulatory therapies exist but have severe and permanent side effects (which is why they aren't used and you don't really hear about them).

So i'd be weary about going around and telling people that they've come up with a cure for these diseases using a pacemaker, but that would be wrong.
 
Last edited:
Taters was used by hungarians to treat t cells. Westboro has share testil mang webs and modems. It could just be that the interference from sal get. Oil even livers moist and gelato we gone make it we mon.
 

Members online

Trending content

Thread statistics

Created
-,
Last reply from
-,
Replies
198
Views
10
Back
Top
Menu
Your profile
Post thread…